According to a lot of cases around me, it is absolutely possible to get itchy eyes due to long-time fatigue, or bad use of your eyes, because improper use of eyes could generate
lots of consequent problems, such as dry eyes, itchy eyes, even infections. So you should be careful. Nevertheless, some diseases such as red eyes could also lead to itchy eyes. So it would be wise of you to see a doctor and take an eye exam first.
It is possible for you to get itchy eyes because of fatigue. If you are fatigue, your eyes nerves will be intense. Your eyes will easily get infection because of the coming invisible bacterium. That is why your eyes get itchy. You could use the eye drops to release the symptom. The warm compress is also a good home remedy.