Yes, it is quite that eye strain can lead to a headache, This is because that the nerves of the whole body are connected with each other. If the eyes get strain due to overuse of the eyes without adequate rest, then the ophthalmic nerves will conduct self neuro regulation by swelling or contracting, thus making the head aches. In another case, if the eyes get strain and feel dry and pain, the blood vessels of the eyes will also frequently stretch and contract after the stimulation, then people will get the cluster headache syndrome. Therefore, people should pay attention not to overuse your eyes. You should have adequate rest and sleep everyday. Do not usually stay up too late at night. Eat more vegetables and fruits to supplement vitamins for your eyes. Regularly do some eye exercises every day.