As long as you do not let the light of the optical mouse directly shoot into the eyes, the optical mouse can not do much harm to your eyes. The optical mouse applies the light beams of the light-emitting diode which are in sent in the way of diffusion. Thus the light sources will get weaker and weaker with the increase of distance, which can affect the reflection of the light sources. If the light shoots directly into the eyes, its high-power energy will certainly do some harm to the eyes, making the eyes feel blurry and pain. Therefore, just make sure the light does not shoot directly into your eyes so that the harm of the optical mouse to your eyes can be reduced to the least level.