Yea, chances are that eye irritation can lead to blindness. A variety of factors can cause eye irritation. Some simple causes such as air pollution and glare from lighting are easy to deal with. In these cases, just keep away from the allergens and rinse your eyes with the clean water to make you feel better or you can use over-the-counter or prescription medications to ease irritation. However, some eye irritation can be an indication of some health problems such as corneal ulcer, dry eye syndrome, conjunctivitis and blepharitis, among which corneal ulcer can contribute to blindness if the ulcer is severe.Under such circumstances, you should go to consult your eye doctor as early as possible and check out the cause so as to receive relevant treatment. Do not delay the treatment, otherwise you are likely to be blind.