Well, generally speaking, photophobia is one eye discomfort in bright light. And you should know that there are many reasons which can lead to photophobia, such as many eye disorders, problems and conditions. Also, an infection or inflammation that irritates the eyes can cause photophobia. On the other hand, according to some researches, glaucoma can cause damage to the optic nerve as a result of increased pressure within the eye. In common, it can be caused by aevere eye infections, injuries, blocked blood vessels or inflammatory conditions of the eye. So we can say that glaucoma can lead to photophobia.