You can make your baby's head a little upward, tease baby with a toy in the direction of his or her head, in order to let him or her look up. Pull open the lower eyelid, drip the eye drops in the lower eyelid, then let your baby close eyes for 1 to 2 minutes, after he or she open eyes, you can use handkerchief to wipe the drops around his or her eyes. For the uncooperative baby, you should have an assistant to help you. You can sit with the assistant face to face, make your baby lie on your knees, his or her legs are clipped on the assistant's two armpits, make baby's head fix on your knee, assistant hold on the baby's arms and body, when baby's body are fixed, you can drip eye drops for the baby. You can also let your baby lie in bed, and ask assistant fix his or her arms, and legs, then you fix the head and drip eye drops.