As a matter of fact, many factors can lead to eye twitching, and depression is one of the factors. Eye twitching is really uncomfortable and annoying, but it is not painful or harmful. Most people develop a minor eyelid twitch at some point in their lives. In most cases, it can recover by its own. In general, Fatigue is the most common reason that cause eye twitching. For example, if you stay up and overuse your eyes, you may get eye twitching the next morning. Besides, Stress and depression can also lead to eye twitching. As we all know bad mood and negative feeling is harmful to our health. In the last, If you take much coffee or drink much tea, you have high chance to get eye twitching, because coffee and tea is rich in caffeine which can lead to eye twitching.