No, it is impossible to have vision loss from pinguecula. Pinguecula is a conjunctival degeneration, which is not cancerous. It is a yellowish bump of thicker fiber degenerated from collagen in eyes, often occurring on the side near to nose. It is not a tumor but just a deposit of protein and fat. It won't grow onto the cornea. According to research now, it might be caused by long time exposure to UV rays or chronic eye irritations. Usually it is not so harmful but annoying. It brings irritations but grows very slow and will lead nothing serious problem. It is very common for aged person. Some people thought it makes them look old and there is a cosmetic surgery procedure which can remove the pinguecula.