Absolutely yes. Fashion nerdy glasses can be made with prescription lenses as you like. In fact, any type of eyeglasses frame can be made with prescription lenses, They only thing you shall be cautious is your prescription. If you need vision aids, you'd better take an eye exam first for a prescription so as to order properly prescription eyeglasses.
Of course. You can take your fashion nerd frame to the eyeglasses store and ask for the lenses replacement service. They can customize your fashion nerd glasses and processed the lenses which can be fitted with your frame. Hope this helpful.