Yes, there is quite a possibility that using mascara can lead to itchy eyes. In some cases there may be an allergic reaction to the mascara, which is because that there are various kinds of chemicals contained in the mascara that may be an irritation to your eyes. Treatment of allergy involves removing the offending agent and facilitating recovery, often with allergy medicine as well as some antibiotic eye drops or eyewash solutions. Therefore, you should take care when you are wearing mascara and prevent it fall into your eyes to cause any eye problems. On the other hand, when buying makeup, you should pay attention to buy products with good quality instead of choosing cheap or new brands in case that your skin or eyes might as well be sensitive or even allergy to the new mascara. In addition, remember to do good and thorough job of cleaning the makeup by using good quality cleansing oil and mildy wash to remove the makeup on the face everyday before you go to bed.