Eye infection is mainly caused by bacterial or viral infection in the eye. By the large, if your eyes are infected, you can suffer from itching, redness, pink eye,swelling, watering, tiredness ,pain and burning. So if your eyes pain and are watery, it is very likely indicative of eye infection. But there still exists an condition where your watery and painful eyes are just due to lack of sleep. We all have the experience if we are utterly tired and sleepy, or eyes could pain and can't help yawning and getting watery eyes. So my suggestion is that you get enough sleep first and check if your pain and watery eyes will get better. If not, you may have a consideration about eye infection.