Well, yes, it is normal to have eye pain when the plane takes off. Generally speaking, flying can lead to eye pressure. First, you should know that if you take airplane, you will make your eyes suffer from many difficult and dangerous problems, such as the eye strains. We can say that when you take the fly, there will have gravity, and it can give you a kind of pressure on your eyes. At that moment, it can just increase the eye pressure. And then it will just affect your eyes, leading to eye pain, and sometimes, bloodshot eyes can occur too. Also, for some people who have taken some eye surgery, it can be dangerous to take a plane. But on the other hand, it will be fine in several minutes.