In some cases, yes, a chemo is possible to cause eye floaters. In general, almost all kinds of cancer chemotherapy drugs have their side effects, such as the effects on the visual system. For example, some drugs can cause tear deficiency in the eyes which leads to discomfort and some blurring of vision. Other chemotherapy drugs can promote the formation of cataracts which reduce the clarity of vision. Still other cancer-treating drugs can cause optic neuropathy, a deterioration of the optic nerve which carries vision information from the eye to the brain. Therefore, it is very important to mention any vision changes that you grandma is having with her doctor so that a referral can be made to your grandma in time. Besides, eye floaters are most common among the group of aged people. As people are aging, the vitreous and its millions of fine collagen fibers shrink and become shred-like. Shreds can accumulate in the vitreous. This can cause a change in the amount of light that hits the retina, which is the light-sensitive tissue in the back of the eye, which causes the symptoms of eye floaters. Your grandma had better go to the doctor's to have an examination to find out whether her eye floaters are caused by the chemo or the reason of aging.