If you spend too much time in front of computers, it surely impact your eyes. Long term staring at the monitor would reduce the frequency of blinking and cause eye strain. As to the mouse laser, there are two different kinds of mice, optic mice and laser mice. Optic mice usually give out red light or sometimes blue light, which is led light. It is better not to staring at the light. Normal application of the optic mice would not cause damages to the eyes, because we can't see any light in the normal application. As to laser mice, the light is invisible for human eyes. You should not to look at it too. Laser mice are more sensitive to the movement and they are more accurate. Anyway, mice are not to be looked at, they are to be moved. Don't try to look at the light or no light to avoid possible damages. Don't let children play it too.